RAS BiologyОнтогенез Russian Journal of Developmental Biology

  • ISSN (Print) 0475-1450
  • ISSN (Online) 3034-6266

Generation of a Null Mutation of the toothrin Gene by Targeted Homologous Recombination in Drosophila melanogaster

PII
10.31857/S0475145023030059-1
DOI
10.31857/S0475145023030059
Publication type
Status
Published
Authors
Volume/ Edition
Volume 54 / Issue number 3
Pages
232-238
Abstract
Drosophila toothrin gene is related to the conserved d4 family of genes that encode specific transcription factors. In early works, we investigated the effect of tth gene overexpression and characterized the specific pattern of its expression in the nervous system, but mutations in the tth gene have not yet been found. Null mutants are essential for analyzing gene function and screening of partner genes. Here we report the generation of the first tth gene knockout in Drosophila using a homologous recombination technique.
Keywords
нокаут гена семейство генов <i>d4</i> <i>toothrin</i> <i>Drosophila melanogaster</i>
Date of publication
18.09.2025
Year of publication
2025
Number of purchasers
0
Views
14

References

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