- PII
- 10.31857/S0475145023030060-1
- DOI
- 10.31857/S0475145023030060
- Publication type
- Status
- Published
- Authors
- Volume/ Edition
- Volume 54 / Issue number 3
- Pages
- 226-231
- Abstract
- The subfornical organ (SFO) is one of the circumventricular organs (CVOs) of the mammalian nervous system responsible for maintaining the energy and water and sodium balance. Despite notable interest in the SFO and its physiological functions, the organization of individual populations of SFO cells, as well as their interactions remain to be clearly established. In this study we examined GABA and nitroxidergic systems of SFO using immunohistochemical (IHC) methods. The brain of male Wistar rats at different stages of postnatal development: postnatal day 7 (P7), 14 (P14) and adult (4–6 months), was examined. The data obtained allowed us to characterize changes in the activity of the GABA- and nitroxidergic systems of the SFO during development. In adult rats, three subpopulations of nitroxidergic cells, differing in the intensity of the reaction and tissue localization, can be distinguished. The revealed morphological heterogeneity of nitroxidergic cells in SFO may reflect their diverse functional status.
- Keywords
- гамма-аминомасляная кислота оксид азота головной мозг субфорникальный орган развитие иммуногистохимия
- Date of publication
- 18.09.2025
- Year of publication
- 2025
- Number of purchasers
- 0
- Views
- 14
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